Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dopaminergic Neurons Differentiated from LRRK2 I1371V-Induced Pluripotent Stem Cells Display a Lower Yield, α-Synuclein Pathology, and Functional Impairment

25 Aug 2022

Abstract excerpt

Being a large multidomain protein, LRRK2 has several confirmed pathological mutant variants for PD, and the incidence of these variants shows ethnicity biases. I1371V, a mutation in the GTPase domain, has been reported in East-Asian populations, but there are no studies reported on dopaminergic (DA) neurons differentiated from this variant. The aim here was to assess the yield, function, and α-synuclein pathology...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve injury and regeneration
Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36006382
DOI: 10.1021/acschemneuro.2c00297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dopaminergic Neurons Differentiated from LRRK2 I1371V-Induced Pluripotent Stem Cells Display a Lower Yield, α-Synuclein Pathology, and Functional ImpairmentPMID 36006382Read ↗

Impaired Sonic Hedgehog Responsiveness of Induced Pluripotent Stem Cell-Derived Floor Plate Cells Carrying the LRRK2-I1371V Mutation Contributes to the Ontogenic Origin of Lower Dopaminergic Neuron Yield.Semantic proximity Read ↗

Diverging Parkinson’s Disease Pathology between patient-derived <i> GBA <sup>N370S</sup> , LRRK2 <sup>G2019S</sup> </i> and engineered <i> SNCA <sup>A53T</sup> </i> iPSC-derived Dopaminergic NeuronsSemantic proximity Read ↗

Induced pluripotent stem cell‐based modeling of mutant LRRK 2‐associated Parkinson's diseaseSemantic proximity Read ↗

Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cellsSemantic proximity Read ↗

Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson’s diseaseSemantic proximity Read ↗

Disease‐specific phenotypes in dopamine neurons from human iPS‐based models of genetic and sporadic Parkinson's diseaseSemantic proximity Read ↗

Dopamine and cortical iPSC-derived neurons with different Parkinsonian mutations show variation in lysosomal and mitochondrial dysfunction: implications for protein deposition versus selective cell lossSemantic proximity Read ↗

Impaired dopamine D3 and nicotinic acetylcholine receptor membrane localization in iPSCs-derived dopaminergic neurons from two Parkinson's disease patients carrying the LRRK2 G2019S mutation.Semantic proximity Read ↗

Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression.Semantic proximity Read ↗

Parkinson’s disease phenotypes in patient specific brain organoids are improved by HP-β-CD treatmentSemantic proximity Read ↗

Comparative study of enriched dopaminergic neurons from siblings with Gaucher disease discordant for parkinsonismSemantic proximity Read ↗

The LRRK2 kinase substrates Rab8a and Rab10 contribute complementary but distinct disease-relevant phenotypes in human neuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.