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Article

Dysfunction of synaptic endocytic trafficking in Parkinson’s disease

1 Mar 2024

Abstract excerpt

Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the striatum. The precise reasons behind the specific degeneration of these dopamine neurons remain largely elusive. Genetic investigations have identified over 20 causative PARK genes and 90 genomic risk loci associated with both familial and sporadic Parkinson's disease....

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PMID: 38595283
DOI: 10.4103/nrr.nrr-d-23-01624

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