Article
Neuroblastoma genetics and phenotype: a tale of heterogeneity.
Seminars in cancer biology - 1 Oct 2011
Speleman Frank, De Preter Katleen, Vandesompele Jo
Abstract excerpt
Cancer is a complex disease driven by multiple genetic and epigenetic alterations. Understanding the (epi-)genetic changes and consequent deregulation of regulatory networks controlling the various normal critical cellular phenotypes that are perturbed in cancer cells can provide clues to new therapeutic opportunities. Moreover, such insights into the molecular pathology of a given cancer type can offer clinical...
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