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Article

Integrated CGH/WES Analyses Advance Understanding of Aggressive Neuroblastoma Evolution: A Case Study.

Cells - 9 Oct 2021

Corallo Diana, Zanon Carlo, Pantile Marcella, Tonini Gian Paolo, Zin Angelica, Francescato Samuela, Rossi Bartolomeo, Trevisson Eva, Pinato Claudia, Monferrer Ezequiel, Noguera Rosa, Aliño Salvador F, Herrero Maria Jose, Biffi Alessandra, Viscardi Elisabetta, Aveic Sanja

Abstract excerpt

Neuroblastoma (NB) is the most common extra-cranial malignancy in preschool children. To portray the genetic landscape of an overly aggressive NB leading to a rapid clinical progression of the disease, tumor DNA collected pre- and post-treatment has been analyzed. Array comparative genomic hybridization (aCGH), whole-exome sequencing (WES), and pharmacogenetics approaches, respectively, have identified relevant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34685674
DOI: 10.3390/cells10102695
PMCID: PMC8534916

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