Article

TLR2 Supports γδ T cell IL-17A Response to ocular surface commensals by Metabolic Reprogramming

2024-04-01

Abstract excerpt

<h4>ABSTRACT</h4> The ocular surface is a mucosal barrier tissue colonized by commensal microbes, which tune local immunity by eliciting IL-17 from conjunctival γδ T cells to prevent pathogenic infection. The commensal Corynebacterium mastitidis ( C. mast ) elicits protective IL-17 responses from conjunctival Vγ4 T cells through a combination of γδ TCR ligation and IL-1 signaling. Here, we identify Vγ6 T cells...

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Literature Corpus work: 9567cf31-1043-528f-bebc-aad1e4c721d4
DOI: 10.1101/2024.04.01.587519

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