Article
An immunobiliary single-cell atlas resolves crosstalk of type 2 cDCs and γδT cells in cholangitis
2025-07-15
Abstract excerpt
<h4>Background and aims</h4> The immunobiliary niche serves as a reservoir of tissue-resident immune cells, yet the role of unconventional T cells during cholangitis remains poorly understood. Here, we connect cell state dynamics of type 2 conventional dendritic cells (cDC2) in cholangitis with site-specific γδ T17 responses in liver and draining lymph nodes (LN). <h4>Methods</h4> The 0.1% Diethoxycarbonyl-1,4...
Topics
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- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Single-cell and spatial transcriptomics
Identifiers and source
- Literature Corpus work
- a3228e3f-c98c-5db9-82a7-1bd712e29ae9
- DOI
- 10.1101/2025.07.10.664083
