Article
CD3bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+ T cells.
Immunology and cell biology - 1 Feb 2015
Paget C, Chow M T, Gherardin N A, Beavis P A, Uldrich A P, Duret H, Hassane M, Souza-Fonseca-Guimaraes F, Mogilenko D A, Staumont-Sallé D, Escalante N K, Hill G R, Neeson P, Ritchie D S, Dombrowicz D, Mallevaey T, Trottein F, Belz G T, Godfrey D I, Smyth M J
Abstract excerpt
Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that has an important role at mucosal sites in a wide range of immune responses including infection, allergy and auto-immunity. γδ T cells are recognized as IL-17 producers, but based on the level of CD3 expression, we now define the remarkable ability of a CD3(bright) γδ T-cell subset with an effector memory phenotype to rapidly produce IL-17A, but not...
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