Article

Spatial genomics maps the structure, character and evolution of cancer clones

2021-04-16

Abstract excerpt

Subclonality is a universal feature of cancers yet how clones grow, are spatially organised, differ phenotypically or influence clinical outcome is unclear. To address this, we developed base specific in situ sequencing (BaSISS). In fixed tissues, transcripts harbouring clone-defining mutations are detected, converted into quantitative clone maps and characterised through multi-layered data integration. Applied to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 955904d7-e10c-54f6-a85d-10cf2c18213c
DOI: 10.1101/2021.04.16.439912

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial genomics maps the structure, character and evolution of cancer clonesDOI 10.1101/2021.04.16.439912Read

Spatial genomics maps the structure, nature and evolution of cancer clones.Semantic proximity Read

Spatial genomics enables multi-modal study of clonal heterogeneity in tissues.Semantic proximity Read

Geospatial genetic evolution and phenotypic plasticity in triple-negative breast cancer.Semantic proximity Read

Subclonal heterogeneity and evolution in breast cancerSemantic proximity Read

cloneMap: a R package to visualise clonal heterogeneitySemantic proximity Read

Detection of Somatic Point Mutations Directly from Spatial Transcriptomics Enables in vivo Spatiotemporal Lineage TracingSemantic proximity Read

Resolving the immune response across clonal cancer evolution in situ with whole transcriptome profilingSemantic proximity Read

Genetic barcoding uncovers the clonal makeup of solid and liquid biopsies and their ability to capture intra-tumoral heterogeneitySemantic proximity Read

DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenograftsSemantic proximity Read

Mitochondrial clone tracing within spatially intact human tissuesSemantic proximity Read

AI-Driven Spatial Transcriptomics Unlocks Large-Scale Breast Cancer Biomarker Discovery from HistopathologySemantic proximity Read

Genetic barcoding of individual cells links cancer evolutionary trajectories and prognostic outcomesSemantic proximity Read