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Article

Geospatial genetic evolution and phenotypic plasticity in triple-negative breast cancer.

Genome medicine - 10 Jun 2026

Hong Ruoxi, Wu Pin, Qiu Yuyue, Dong Shichen, Huang Yuhan, Lee Kaping, Wang Huifang, Li Mei, Zhang Cuijuan, Ye Feng, Mo Shanlan, Xue Siming, Wu Wei, Hu Zheng, Zhang Weimin, Zhan Qimin, Li Guibo, Wang Shusen

Abstract excerpt

BACKGROUND: The interplay between genotype and phenotype in shaping spatial heterogeneity and metastatic evolution in triple-negative breast cancer (TNBC) remains poorly understood. METHODS: Here, we developed a pathology-guided geospatial genomic and transcriptomic sequencing workflow (pGeo-G&T-seq) and applied it to TNBC specimens from primary tumors and matched metastatic sites. Using laser capture...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42271485
DOI: 10.1186/s13073-026-01684-0
PMCID: PMC13474512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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