Article

Genetic barcoding uncovers the clonal makeup of solid and liquid biopsies and their ability to capture intra-tumoral heterogeneity

2025-06-17

Abstract excerpt

Intra-tumoral heterogeneity (ITH) is fueling tumor progression in breast cancer, as specific clones present within a tumor may have a selective advantage to colonize distant organs and escape therapy. Accurate sampling of ITH is therefore a pressing challenge in clinical oncology, to adequately predict recurrence and inform rational and personalized therapies. Here we used cellular barcoding to track the spatio-te...

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Literature Corpus work: 0bf61ff2-d45c-5ea5-a1bc-9000612375c3
DOI: 10.1101/2025.06.12.659267

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