Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spatial genomics enables multi-modal study of clonal heterogeneity in tissues.

Nature - 1 Jan 2022

Zhao Tongtong, Chiang Zachary D, Morriss Julia W, LaFave Lindsay M, Murray Evan M, Del Priore Isabella, Meli Kevin, Lareau Caleb A, Nadaf Naeem M, Li Jilong, Earl Andrew S, Macosko Evan Z, Jacks Tyler, Buenrostro Jason D, Chen Fei

Abstract excerpt

The state and behaviour of a cell can be influenced by both genetic and environmental factors. In particular, tumour progression is determined by underlying genetic aberrations1-4 as well as the makeup of the tumour microenvironment5,6. Quantifying the contributions of these factors requires new technologies that can accurately measure the spatial location of genomic sequence together with phenotypic readouts....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clone Cells
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Genomics

Share to RNA-Seq

Share to Sequence Analysis, DNA

Share to Transcription, Genetic

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 34912115
DOI: 10.1038/s41586-021-04217-4
PMCID: PMC9301586

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spatial genomics enables multi-modal study of clonal heterogeneity in tissues.PMID 34912115Read ↗

Spatial genomics maps the structure, nature and evolution of cancer clones.Semantic proximity Read ↗

The spatial landscape of clonal somatic mutations in benign and malignant tissueSemantic proximity Read ↗

The spatial landscape of clonal somatic mutations in benign and malignant tissueSemantic proximity Read ↗

Single Cell Sequencing: Genomic and Transcriptomics Approaches in Cancer Cell BiologySemantic proximity Read ↗

Moving closer towards a comprehensive view of tumor biology and microarchitecture using spatial transcriptomicsSemantic proximity Read ↗

Spatial genomics maps the structure, character and evolution of cancer clonesSemantic proximity Read ↗

Mapping Spatial Genetic Landscapes in Tissue Sections through Microscale Integration of Sampling Methodology into Genomic Workflows.Semantic proximity Read ↗

Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analysesSemantic proximity Read ↗

Spatial RNA sequencing methods show high resolution of single cell in cancer metastasis and the formation of tumor microenvironmentSemantic proximity Read ↗

Chromosomal instability shapes spatial and temporal phenotypic diversity in a malignant peripheral nerve sheath tumourSemantic proximity Read ↗

Slide-tags: scalable, single-nucleus barcoding for multi-modal spatial genomicsSemantic proximity Read ↗

Analysis of Spatial Molecular Data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.