Article
Spatial genomics maps the structure, nature and evolution of cancer clones.
Nature - 1 Nov 2022
Lomakin Artem, Svedlund Jessica, Strell Carina, Gataric Milana, Shmatko Artem, Rukhovich Gleb, Park Jun Sung, Ju Young Seok, Dentro Stefan, Kleshchevnikov Vitalii, Vaskivskyi Vasyl, Li Tong, Bayraktar Omer Ali, Pinder Sarah, Richardson Andrea L, Santagata Sandro, Campbell Peter J, Russnes Hege, Gerstung Moritz, Nilsson Mats, Yates Lucy R
Abstract excerpt
Genome sequencing of cancers often reveals mosaics of different subclones present in the same tumour1-3. Although these are believed to arise according to the principles of somatic evolution, the exact spatial growth patterns and underlying mechanisms remain elusive4,5. Here, to address this need, we developed a workflow that generates detailed quantitative maps of genetic subclone composition across whole-tumour...
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