Article

Microglia/macrophage-specific deletion of TLR-4 protects against neural effects of diet-induced obesity

2024-02-14

Abstract excerpt

Obesity is associated with numerous adverse neural effects, including reduced neurogenesis, cognitive impairment, and increased risks for developing Alzheimer’s disease (AD) and vascular dementia. Obesity is also characterized by chronic, low-grade inflammation that is implicated in mediating negative consequences body-wide. Toll-like receptor 4 (TLR4) signaling from peripheral macrophages is implicated as an esse...

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Literature Corpus work: 9543589a-97f0-5e56-8dfb-b43f6a777339
DOI: 10.1101/2024.02.13.580189

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