Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diet-Induced Obesity Elicits Macrophage Infiltration and Reduction in Spine Density in the Hypothalami of Male but Not Female Mice

11 Sept 2018

Abstract excerpt

Increasing prevalence in obesity has become a significant public concern. C57BL/6J mice are prone to diet-induced obesity (DIO) when fed high-fat diet (HFD), and develop chronic inflammation and metabolic syndrome, making them a good model to analyze mechanisms whereby obesity elicits pathologies. DIO mice demonstrated profound sex differences in response to HFD with respect to inflammation and hypothalamic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Regulation of Appetite and Obesity
Share to Stress Responses and Cortisol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30254630
DOI: 10.3389/fimmu.2018.01992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diet-Induced Obesity Elicits Macrophage Infiltration and Reduction in Spine Density in the Hypothalami of Male but Not Female MicePMID 30254630Read ↗

Microglia/macrophage-specific deletion of TLR-4 protects against neural effects of diet-induced obesitySemantic proximity Read ↗

Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice.Semantic proximity Read ↗

Sex Differences in Macrophage Responses to Obesity-Mediated Changes Determine Migratory and Inflammatory TraitsSemantic proximity Read ↗

Ketogenic diet alters microglial morphology and changes the hippocampal lipidomic profile distinctively in stress susceptible <i>versus</i> resistant male mice upon repeated social defeatSemantic proximity Read ↗

Maternal High-Energy Diet during Pregnancy and Lactation Impairs Neurogenesis and Alters the Behavior of Adult Offspring in a Phenotype-Dependent Manner.Semantic proximity Read ↗

PPARγ-mediated microglial activation phenotype is involved in depressive-like behaviors and neuroinflammation in stressed C57BL/6J and ob/ob mice.Semantic proximity Read ↗

Progressive hypothalamic neuroinflammation after ovariectomy in mice parallels age-related transcriptomic changes in the female human hypothalamusSemantic proximity Read ↗

Fat food exacerbates post-prandial hypothalamic inflammation involving GFAP+ cells and microgliaSemantic proximity Read ↗

Maternal diet disrupts the placenta-brain axis in a sex-specific mannerSemantic proximity Read ↗

Supraphysiologic doses of 17β-Estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolismSemantic proximity Read ↗

Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophilsSemantic proximity Read ↗

Enduring consequences of maternal obesity for brain inflammation and behavior of offspring.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.