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Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction

29 Apr 2024

Abstract excerpt

Obesity increases the morbidity and mortality of traumatic brain injury (TBI). Detailed analyses of transcriptomic changes in the brain and adipose tissue were performed to elucidate the interactive effects between high-fat diet-induced obesity (DIO) and TBI. Adult male mice were fed a high-fat diet (HFD) for 12 weeks prior to experimental TBI and continuing after injury. High-throughput transcriptomic analysis...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Traumatic Brain Injury and Neurovascular Disturbances

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PMID: 38685031
DOI: 10.1186/s12974-024-03107-6

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