Article
Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice.
Nature communications - 22 Feb 2017
Dorfman Mauricio D, Krull Jordan E, Douglass John D, Fasnacht Rachael, Lara-Lince Fernando, Meek Thomas H, Shi Xiaogang, Damian Vincent, Nguyen Hong T, Matsen Miles E, Morton Gregory J, Thaler Joshua P
Abstract excerpt
Female mice are less susceptible to the negative metabolic consequences of high-fat diet feeding than male mice, for reasons that are incompletely understood. Here we identify sex-specific differences in hypothalamic microglial activation via the CX3CL1-CX3CR1 pathway that mediate the resistance of female mice to diet-induced obesity. Female mice fed a high-fat diet maintain CX3CL1-CX3CR1 levels while male mice...
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