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Article

PPARγ-mediated microglial activation phenotype is involved in depressive-like behaviors and neuroinflammation in stressed C57BL/6J and ob/ob mice.

Psychoneuroendocrinology - 1 Jul 2020

Qin Xiaqing, Wang Wei, Wu Huiran, Liu Dexiang, Wang Rui, Xu Jingjing, Jiang Hong, Pan Fang

Abstract excerpt

BACKGROUND: There is an increased risk for obese patients with chronic low-grade inflammation to develop depression. Stress induces microglial activation and neuroinflammation that play crucial roles in the pathogenesis of depression. Peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear transcription factor, regulates microglial polarization and neuroinflammation. Our study aimed to investigate the...

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PMID: 32422516
DOI: 10.1016/j.psyneuen.2020.104674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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