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Article

TLR4 mutation protects neurovascular function and cognitive decline in high-fat diet-fed mice.

Journal of neuroinflammation - 29 Apr 2022

Obadia Nathalie, Andrade Giulia, Leardini-Tristão Marina, Albuquerque Letícia, Garcia Celina, Lima Flavia, Daleprane Júlio, Castro-Faria-Neto Hugo C, Tibiriçá Eduardo, Estato Vanessa

Abstract excerpt

BACKGROUND: Metabolic syndrome (MS) is defined as a low-grade proinflammatory state in which abnormal metabolic and cardiovascular factors increase the risk of developing cardiovascular disease and neuroinflammation. Events, such as the accumulation of visceral adipose tissue, increased plasma concentrations of free fatty acids, tissue hypoxia, and sympathetic hyperactivity in MS may contribute to the direct or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35488354
DOI: 10.1186/s12974-022-02465-3
PMCID: PMC9052472

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