Article

Troriluzole Rescues Glutamatergic Deficits, Amyloid and Tau Pathology, and Synaptic and Memory Impairments in 3xTg-AD Mice

2024-06-13

Abstract excerpt

Alzheimer’s disease (AD) is a neurodegenerative condition in which clinical symptoms are highly correlated with the loss of glutamatergic synapses. While later stages of AD are associated with markedly decreased glutamate levels due to neuronal loss, in the early stages, pathological accumulation of glutamate and hyperactivity contribute to AD pathology and cognitive dysfunction. There is increasing awareness that...

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Literature Corpus work: 95400a6e-99c1-5a34-bcc3-0cbe704dc026
DOI: 10.1101/2024.06.11.598453

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