Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases—an update

19 May 2025

Abstract excerpt

Glutamate excitotoxicity is intricately linked to the pathogenesis of neurodegenerative diseases, exerting a profound influence on cognitive functions such as learning and memory in mammals. Glutamate, while crucial for these processes, can lead to neuronal damage and death when present in excessive amounts. Our previous review delved into the cascade of excitotoxic injury events and the underlying mechanisms of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholinesterase and Neurodegenerative Diseases
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Neuroscience and Neuropharmacology Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40389567
DOI: 10.1038/s41401-025-01576-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases—an updatePMID 40389567Read ↗

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseasesSemantic proximity Read ↗

Glutamate Excitotoxicity and NeurodegenerationSemantic proximity Read ↗

Common and divergent pathways in early stages of glutamate and tau-mediated toxicities in neurodegenerationSemantic proximity Read ↗

Glutamate, excitotoxicity, and programmed cell death in Parkinson disease.Semantic proximity Read ↗

Revisiting Glutamate Excitotoxicity in Amyotrophic Lateral Sclerosis and Age-Related NeurodegenerationSemantic proximity Read ↗

Potential Astrocytic Receptors and Transporters in the Pathogenesis of Alzheimer’s DiseaseSemantic proximity Read ↗

Neuroprotective strategies for NMDAR-mediated excitotoxicity in Huntington’s DiseaseSemantic proximity Read ↗

Common Mechanisms of Neuronal Dysfunction in Neurodegenerative Diseases: Insights and Therapeutic StrategiesSemantic proximity Read ↗

Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer’s Disease, a Potential Therapeutic TargetSemantic proximity Read ↗

Neuronal cell death in neurodegenerative diseases: recurring themes around protein handlingSemantic proximity Read ↗

Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated ViewSemantic proximity Read ↗

The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.