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Article

7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Feb 2014

Zhang Zhentao, Liu Xia, Schroeder Jason P, Chan Chi-Bun, Song Mingke, Yu Shan Ping, Weinshenker David, Ye Keqiang

Abstract excerpt

Synaptic loss in the brain correlates well with disease severity in Alzheimer disease (AD). Deficits in brain-derived neurotrophic factor/tropomyosin-receptor-kinase B (TrkB) signaling contribute to the synaptic dysfunction of AD. We have recently identified 7,8-dihydroxyflavone (7,8-DHF) as a po...

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Identifiers

PMID: 24022672
DOI: 10.1038/npp.2013.243
PMCID: PMC3895241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24022672-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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