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Cornel Iridoid Glycoside Suppresses Hyperactivity Phenotype in rTg4510 Mice through Reducing Tau Pathology and Improving Synaptic Dysfunction.

Current medical science - 1 Dec 2020

Ma Deng-Lei, Luo Yi, Huang Rui, Zhao Zi-Run, Zhang Li, Li Ya-Li, Wang Qi, Li Lin, Zhang Lan

Abstract excerpt

rTg4510 mice are transgenic mice expressing P301L mutant tau and have been developed as an animal model of tauopathies including Alzheimer's disease (AD). Besides cognitive impairments, rTg4510 mice also show abnormal hyperactivity behavior. Cornel iridoid glycoside (CIG) is an active ingredient extracted from Cornus officinalis, a traditional Chinese herb. The purpose of the present study was to investigate the...

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PMID: 33428130
DOI: 10.1007/s11596-020-2284-z

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