Article

Excitoprotective effects of conditional tau reduction in excitatory neurons and in adulthood

2024-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Tau reduction is a promising therapeutic strategy for Alzheimer’s disease. In numerous models, tau reduction via genetic knockout is beneficial, at least in part due to protection against hyperexcitability and seizures, but the underlying mechanisms are unclear. Here we describe the generation and initial study of a new conditional Tau flox model to address these mechanisms. Given the protectiv...

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Literature Corpus work: 43aff0d0-5f00-56b5-a599-9277c7a3eb0d
DOI: 10.1101/2024.05.14.594246

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