Article

Riluzole shifts glial responses to protect synapses and memory in Aβ oligomer–treated rats

2025-12-27

Abstract excerpt

Soluble Aβ 1-42 (amyloid beta) oligomers are potent neurotoxins that disrupt synaptic function, alter glial responses, and lead to memory impairment in Alzheimer’s disease (AD). Riluzole, a glutamate modulator approved for amyotrophic lateral sclerosis, reduces neuronal hyperexcitability, yet its in vivo effects on Aβ oligomer–induced cognitive dysfunction and glial alterations remain incompletely understood. He...

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Literature Corpus work: 05dfe672-5d5d-5064-91d7-ea985002cfcd
DOI: 10.64898/2025.12.26.696626

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