Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elevation of brain magnesium prevents and reverses cognitive deficits and synaptic loss in Alzheimer's disease mouse model.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 May 2013

Li Wei, Yu Jia, Liu Yong, Huang Xiaojie, Abumaria Nashat, Zhu Ying, Huang Xian, Xiong Wenxiang, Ren Chi, Liu Xian-Guo, Chui Dehua, Liu Guosong

Abstract excerpt

Profound synapse loss is one of the major pathological hallmarks associated with Alzheimer's disease (AD) and might underlie memory impairment. Our previous work demonstrated that the magnesium ion is a critical factor in controlling synapse density/plasticity. Here, we investigated whether elevation of brain magnesium by the use of a recently developed compound, magnesium-l-threonate (MgT), can ameliorate the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Butyrates
Share to Exploratory Behavior

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamate Decarboxylase

Share to Magnesium

Share to Maze Learning

Share to Neuroprotective Agents

Share to Presynaptic Terminals

Share to Reaction Time

Source

Open in PubMed Open full text

Identifiers

PMID: 23658180
DOI: 10.1523/JNEUROSCI.4610-12.2013
PMCID: PMC6619649

Genes

BACE1
APP
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elevation of brain magnesium prevents and reverses cognitive deficits and synaptic loss in Alzheimer's disease mouse model.PMID 23658180Read ↗

Magnesium boosts the memory restorative effect of environmental enrichment in Alzheimer's disease mice.Semantic proximity Read ↗

Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant.Semantic proximity Read ↗

Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer’s diseaseSemantic proximity Read ↗

Presenilins and APP in neuritic and synaptic plasticity: implications for the pathogenesis of Alzheimer's disease.Semantic proximity Read ↗

mGluR5 Contribution to Neuropathology in Alzheimer Mice Is Disease Stage-DependentSemantic proximity Read ↗

Orally active mGluR2/3 metabotropic antagonist pro-drug mimics the beneficial effects of physical exercise on neurogenesis, behavior, and exercise-related molecular pathways in an Alzheimer’s disease mouse modelSemantic proximity Read ↗

AETA peptide drives Alzheimer’s disease signature of synapse dysfunctionSemantic proximity Read ↗

Opposing actions of environmental enrichment and Alzheimer’s disease on the expression of hippocampal microRNAs in mouse modelsSemantic proximity Read ↗

Neurogranin restores amyloid β-mediated synaptic transmission and long-term potentiation deficits.Semantic proximity Read ↗

Glial Sphingosine-Mediated Epigenetic Regulation Stabilizes Synaptic Function inDrosophilaModels of Alzheimer's DiseaseSemantic proximity Read ↗

Potential Astrocytic Receptors and Transporters in the Pathogenesis of Alzheimer’s DiseaseSemantic proximity Read ↗

Oral treatment with a gamma-secretase inhibitor improves long-term potentiation in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.