Article

A codon-sensitive conformational switch gates commitment to translation start sites

2026-03-27

Abstract excerpt

Human translation initiation requires single-nucleotide precision to establish the reading frame, yet initiation at non-AUG codons plays key roles in gene expression. How the initiation machinery balances precision with this regulated flexibility remains unclear. Here, we define a conformational branchpoint governed by the human initiation factor eIF5 that gates commitment to start codons. Using single-molecule an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6fafc651-5aff-5926-ac36-a301497fa25f
DOI: 10.64898/2026.03.24.713952

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A codon-sensitive conformational switch gates commitment to translation start sitesDOI 10.64898/2026.03.24.713952Read

Decoding the Sequence Requirements for Translation InitiationSemantic proximity Read

The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β.Semantic proximity Read

Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.Semantic proximity Read

Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex.Semantic proximity Read

Mechanisms Leading to the Loss of AUG Codon Function as a Translation InitiatorSemantic proximity Read

eIF5 and eIF5B together stimulate 48S initiation complex formation during ribosomal scanning.Semantic proximity Read

Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex.Semantic proximity Read

Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome.Semantic proximity Read

Mammalian Alternative Translation Initiation Is Mostly Nonadaptive.Semantic proximity Read

The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.Semantic proximity Read

Sequential eukaryotic translation initiation factor 5 (eIF5) binding to the charged disordered segments of eIF4G and eIF2β stabilizes the 48S preinitiation complex and promotes its shift to the initiation mode.Semantic proximity Read

Principles of start codon recognition in eukaryotic translation initiation.Semantic proximity Read