Article

ATF4 programs proline-dependent immune evasion in β-Catenin-driven hepatocellular carcinoma

2026-05-16

Abstract excerpt

<h4>Background & Aims</h4> Hepatocellular carcinoma (HCC) frequently exhibits resistance to immune checkpoint inhibitors (ICIs), particularly in β -catenin-driven tumors characterized by immune exclusion. While the Unfolded Protein Response (UPR) and the Integrated Stress Responses (ISR) enable tumor adaptation to metabolic stress their role in shaping tumor immunogenicity remains incompletely understood. We inve...

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Literature Corpus work: 9530d0cd-9db0-5bdf-a092-bce8f3ff7eb5
DOI: 10.64898/2026.05.12.724215

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