Article

Single-Cell Transcriptomic Profiling Reveals Immunometabolic Reprogramming and Cell-Cell Communication in the Tumor Microenvironment of Human Hepatocellular Carcinoma

2026-03-25

Abstract excerpt

Hepatocellular carcinoma (HCC) is driven by coordinated interactions among malignant hepatocytes, immune cells, and stromal populations that collectively sustain tumor growth, immune evasion, and vascular remodeling. Through integrative single-cell transcriptomic analysis of 159,925 cells from tumor and healthy human liver tissues, we delineated the cell-type-specific transcriptional programs underlying immunometa...

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Literature Corpus work: ebd4b13e-1282-5eda-b614-7050efb12055
DOI: 10.20944/preprints202603.1929.v1

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