Article

Endoplasmic reticulum stress signaling actively contributes to therapy resistance in colorectal cancer

2024-01-08

Abstract excerpt

<h4>Purpose</h4> We investigated the involvement of endoplasmic reticulum (ER) stress signaling in cancer cell responses to chemo- and radiotherapy, focusing on three main ER stress mediators, the transcription factors ATF4, XBP1 and ATF6. <h4>Methods</h4> Public cancer genome datasets were assessed for alterations in ER stress mediators. Surgically resected colorectal cancer tissues were tested by flow cytometr...

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Literature Corpus work: a1a0e5d4-c862-52d1-92fb-c74c40308eca
DOI: 10.1101/2024.01.07.574523

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