Article

ATF2 drives macrophage-mediated anti-PD-1 resistance by coupling KAT3A-dependent H3K18 lactylation with CCL2 transcription in hepatocellular carcinoma

2026-08-25

Abstract excerpt

<title>Abstract</title> <p>Immune checkpoint blockade has improved the treatment of hepatocellular carcinoma (HCC), yet most patients fail to achieve durable responses to PD-1 blockade. Tumor-associated macrophages are major determinants of immunotherapy resistance, but the tumor-intrinsic epigenetic programs that recruit and polarize macrophages in HCC remain incompletely defined. Here, we identify activating tr...

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Literature Corpus work: 1cffe443-050a-5ea6-b19d-af1633da6746
DOI: 10.21203/rs.3.rs-10533707/v1

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