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Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53-associated features

2020-05-02

Abstract excerpt

TP53 gene mutations are very common in human cancer. While such mutations abrogate the tumor suppressive activities of the wild type (wt) p53 protein, some of them also endow the mutant protein with oncogenic gain-of-function (GOF), facilitating cancer progression. Yet, p53 may acquire altered functionality even without being mutated; in particular, experiments with cultured cells revealed that wt p53 can be rewir...

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Literature Corpus work: 9529e83c-8b20-5792-9eff-2d9c83940242
DOI: 10.1101/2020.04.30.070037

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Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53-associated featuresDOI 10.1101/2020.04.30.070037Read

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Transcriptional profiling reveals a subset of human breast tumors that retain wt <i>TP53</i> but display mutant p53-associated features

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