Article
Effects of TP53 mutational status on gene expression patterns across 10 human cancer types.
The Journal of pathology - 1 Apr 2014
Parikh Neha, Hilsenbeck Susan, Creighton Chad J, Dayaram Tajhal, Shuck Ryan, Shinbrot Eve, Xi Liu, Gibbs Richard A, Wheeler David A, Donehower Lawrence A
Abstract excerpt
Mutations in the TP53 tumour suppressor gene occur in half of all human cancers, indicating its critical importance in inhibiting cancer development. Despite extensive studies, the mechanisms by which mutant p53 enhances tumour progression remain only partially understood. Here, using data from the Cancer Genome Atlas (TCGA), genomic and transcriptomic analyses were performed on 2256 tumours from 10 human cancer...
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