Article

Reconstructing the functional effect of <i>TP53</i> somatic mutations on its regulon using causal signalling network modelling

2022-06-26

Abstract excerpt

<h4> A bstract </h4> The gene encoding tumor protein p53 ( TP53 ) is the most frequently mutated gene in human cancer. Mutations in both coding and non-coding regions of TP53 can disrupt the regulatory function of the transcription factor, but the functional impact of different somatic mutations on the global TP53 regulon is complex and poorly understood. To address this, we first proceed with a machine lea...

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Literature Corpus work: 1618fe9e-579c-56a4-bd61-6355325ae3d3
DOI: 10.1101/2022.06.23.497293

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