Article
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival.
Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2005
Miller Lance D, Smeds Johanna, George Joshy, Vega Vinsensius B, Vergara Liza, Ploner Alexander, Pawitan Yudi, Hall Per, Klaar Sigrid, Liu Edison T, Bergh Jonas
Abstract excerpt
Perturbations of the p53 pathway are associated with more aggressive and therapeutically refractory tumors. However, molecular assessment of p53 status, by using sequence analysis and immunohistochemistry, are incomplete assessors of p53 functional effects. We posited that the transcriptional fingerprint is a more definitive downstream indicator of p53 function. Herein, we analyzed transcript profiles of 251...
Topics
- Breast Neoplasms
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Humans
- Mutation
- Oligonucleotide Array Sequence Analysis
- Predictive Value of Tests
- Prognosis
- Transcription, Genetic
- Tumor Suppressor Protein p53