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Article

TP53 missense–specific transcriptional plasticity drives resistance against cell cycle inhibitors in pancreatic cancer

4 Jul 2025

Abstract excerpt

In ~70% of patients with pancreatic ductal adenocarcinoma, the TP53 gene acquires gain-of-function (GOF) mutations leading to rapid disease progression. Specifically, missense p53 (misp53) GOF mutations associate with therapy resistance and worse clinical outcomes. However, the molecular functions of distinct misp53 mutants in plasticity and therapy response remain unclear. Integrating multicenter patient data...

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PMID: 40614202
DOI: 10.1126/sciadv.adu2339

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