When mutants gain new powers: news from the mutant p53 field.

Abstract excerpt

Ample data indicate that mutant p53 proteins not only lose their tumour suppressive functions, but also gain new abilities that promote tumorigenesis. Moreover, recent studies have modified our view of mutant p53 proteins, portraying them not as inert mutants, but rather as regulated proteins that influence the cancer cell transcriptome and phenotype. This influence is clinically manifested as association of TP53...

Topics

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• Disease Models, Animal
• Genes, p53
• Mice
• Mutation
• Neoplasms
• Prognosis