Article
Mutants TP53 p.R273H and p.R273C but not p.R273G enhance cancer cell malignancy.
Human mutation - 1 May 2014
Li Jie, Yang Lixin, Gaur Shikha, Zhang Keqiang, Wu Xiwei, Yuan Yate-Ching, Li Hongzhi, Hu Shuya, Weng Yaguang, Yen Yun
Abstract excerpt
Mutation of the tumor suppressor TP53 gene occurs in greater than half of all human cancers. In addition to loss of tumor suppressor function of wild-type TP53, gain-of-function mutations endow cancer cells with more malignant properties. R273 is a mutation hotspot with the p.R273H, p.R273C, and p.R273G variants occurring most commonly in patient samples. To better understand the consequences of these R273...
Topics
- Apoptosis
- Breast Neoplasms
- Cell Line, Tumor
- Cell Proliferation
- Cisplatin
- Drug Resistance, Neoplasm
- Female
- Humans
- Molecular Dynamics Simulation
- Mutation
- Neoplasm Invasiveness