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Article

Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53-associated features.

Molecular oncology - 1 Aug 2020

Benor Gal, Fuks Garold, Chin Suet-Feung, Rueda Oscar M, Mukherjee Saptaparna, Arandkar Sharathchandra, Aylon Yael, Caldas Carlos, Domany Eytan, Oren Moshe

Abstract excerpt

TP53 gene mutations are very common in human cancer. While such mutations abrogate the tumor suppressive activities of the wild-type (wt) p53 protein, some of them also endow the mutant (mut) protein with oncogenic gain of function (GOF), facilitating cancer progression. Yet, p53 may acquire altered functionality even without being mutated; in particular, experiments with cultured cells revealed that wtp53 can be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32484602
DOI: 10.1002/1878-0261.12736
PMCID: PMC7400784

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