Targeting mutant p53: a key player in breast cancer pathogenesis and beyond.

Abstract excerpt

The p53 mutation is the most common genetic mutation associated with human neoplasia. TP53 missense mutations, which frequently arise early in breast cancer, are present in over thirty percent of breast tumors. In breast cancer, p53 mutations are linked to a more aggressive course of the disease and worse overall survival rates. TP53 mutations are mostly seen in triple-negative breast cancer, a very diverse kind...

Topics

• Animals
• Female
• Humans
• Breast Neoplasms
• Mutation
• Tumor Suppressor Protein p53