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Article

Exchange of extracellular domains of CCR1 and CCR5 reveals confined functions in CCL5-mediated cell recruitment.

Thrombosis and haemostasis - 1 Oct 2013

Kramp Birgit K, Megens Remco T A, Sarabi Alisina, Winkler Sabine, Projahn Delia, Weber Christian, Koenen Rory R, von Hundelshausen Philipp

Abstract excerpt

The chemokine CCL5 recruits monocytes into inflamed tissues by triggering primarily CCR1-mediated arrest on endothelial cells, whereas subsequent spreading is dominated by CCR5. The CCL5-induced arrest can be enhanced by heteromer formation with CXCL4. To identify mechanisms for receptor-specific functions, we employed CCL5 mutants and transfectants expressing receptor chimeras carrying transposed extracellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23925484
DOI: 10.1160/TH13-05-0420

Genes

CCL5
CCR1
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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