Article
Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.
eLife - 8 Jun 2018
Miles Timothy F, Spiess Katja, Jude Kevin M, Tsutsumi Naotaka, Burg John S, Ingram Jessica R, Waghray Deepa, Hjorto Gertrud M, Larsen Olav, Ploegh Hidde L, Rosenkilde Mette M, Garcia K Christopher
Abstract excerpt
Human cytomegalovirus has hijacked and evolved a human G-protein-coupled receptor into US28, which functions as a promiscuous chemokine 'sink' to facilitate evasion of host immune responses. To probe the molecular basis of US28's unique ligand cross-reactivity, we deep-sequenced CX3CL1 chemokine libraries selected on 'molecular casts' of the US28 active-state and find that US28 can engage thousands of distinct...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.