Back to search

Article

Genomic Characterization of Partial Tandem Duplication Involving the KMT2A Gene in Adult Acute Myeloid Leukemia

2024-03-18

Abstract excerpt

<h4>Background: </h4> Gene rearrangements affecting KMT2A are frequent in acute myeloid leukemia (AML) and are often associated with a poor prognosis. KMT2A gene fusions are often detected by chromosome banding analysis and confirmed by fluorescence in-situ hybridization. However, small intragenic insertions, termed KMT2A partial tandem duplication (PTD), are particularly challenging to detect using standard molec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
951b20c2-8d56-56bf-96b9-7799309fbf5e
DOI
10.20944/preprints202403.0904.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genomic Characterization of Partial Tandem Duplication Involving the KMT2A Gene in Adult Acute Myeloid LeukemiaDOI 10.20944/preprints202403.0904.v1
Genomic Characterization of Partial Tandem Duplication Involving the KMT2A Gene in Adult Acute Myeloid LeukemiaSemantic proximity
Unveiling the Complexity of KMT2A Rearrangements in Acute Myeloid Leukemias with Optical Genome MappingSemantic proximity
Detection of KMT2A Partial Tandem Duplication by Optical Genome Mapping in Myeloid Neoplasms: Associated Cytogenetics, Gene Mutations, Treatment Responses, and Patient OutcomesSemantic proximity
Role of Chromosomal Microarray and RNA Fusion Analysis in Detecting <i>KMT2A</i>-PTD and Stem Cell Transplant Impact on MortalitySemantic proximity
KMT2A Rearrangements in Leukemias: Molecular Aspects and Therapeutic PerspectivesSemantic proximity
Allelic complexity of KMT2A partial tandem duplications in acute myeloid leukemia and myelodysplastic syndromes.Semantic proximity
Insights into KMT2A rearrangements in acute myeloid leukemia: from molecular characteristics to targeted therapiesSemantic proximity
Allelic Complexity of <i>KMT2A</i> Partial Tandem Duplications in Acute Myeloid Leukemia and Myelodysplastic SyndromesSemantic proximity
Partial tandem duplication of KMT2A (MLL) may predict a subset of myelodysplastic syndrome with unique characteristics and poor outcomeSemantic proximity
Updates in KMT2A Gene Rearrangement in Pediatric Acute Lymphoblastic LeukemiaSemantic proximity
Acute myeloid leukaemia (AML) harbouring KMT2A-PTD: should it be considered as a myelodysplasia-related abnormality?Semantic proximity
The KMT2A recombinome of acute leukemias in 2023Semantic proximity
Select a neighboring publication to make it the new centre.