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Article

Allelic complexity of KMT2A partial tandem duplications in acute myeloid leukemia and myelodysplastic syndromes.

Blood advances - 26 Jul 2022

Tsai Harrison K, Gibson Christopher J, Murdock H Moses, Davineni Phani, Harris Marian H, Wang Eunice S, Gondek Lukasz P, Kim Annette S, Nardi Valentina, Lindsley R Coleman

Abstract excerpt

KMT2A partial tandem duplication (KMT2A-PTD) is an adverse risk factor in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), a potential therapeutic target, and an attractive marker of measurable residual disease. High initial KMT2A-PTD RNA levels have been linked to poor prognosis, but mechanisms regulating KMT2A-PTD expression are not well understood. Although KMT2A-PTD has been reported to affect...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35584376
DOI: 10.1182/bloodadvances.2022007613
PMCID: PMC9327559

Genes

KMT2A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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