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Allelic Complexity of <i>KMT2A</i> Partial Tandem Duplications in Acute Myeloid Leukemia and Myelodysplastic Syndromes

2021-11-02

Abstract excerpt

KMT2A partial tandem duplication ( KMT2A -PTD) at 11q23.3 is associated with adverse risk in AML and MDS, is a potential therapeutic target, and is an attractive marker of measurable residual disease. High initial KMT2A -PTD RNA levels have been linked to poor prognosis, but mechanisms regulating KMT2A -PTD expression are not well understood. While it has been reported that KMT2A -PTD affects only a single allele,...

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Literature Corpus work
bcbae654-9b4e-5195-842a-368f06b74ac7
DOI
10.1101/2021.11.01.21265781
Open publication

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Allelic Complexity of <i>KMT2A</i> Partial Tandem Duplications in Acute Myeloid Leukemia and Myelodysplastic SyndromesDOI 10.1101/2021.11.01.21265781
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