Back to search

Article

Awakening prime editing for precision engineering of probiotic <i>Escherichia coli</i> Nissle 1917

2024-10-28

Abstract excerpt

CRISPR-Cas systems are transforming precision medicine with engineered probiotics as next-generation diagnostics and therapeutics. To promote human health and treat disease, engineering probiotic bacteria demands maximal versatility to enable non-natural functionalities while minimizing undesired genomic interferences. Here, we present a streamlined prime editing approach tailored for probiotic Escherichia coli N...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
950ede7b-29c8-5d9d-858f-b6df279f4c58
DOI
10.1101/2024.10.28.620590
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Awakening prime editing for precision engineering of probiotic <i>Escherichia coli</i> Nissle 1917DOI 10.1101/2024.10.28.620590
The Advancement and Applications of Prime EditingSemantic proximity
Mobile-CRISPRi: Enabling Genetic Analysis of Diverse BacteriaSemantic proximity
Engineered prime editors with PAM flexibility.Semantic proximity
Make-or-break prime editing for bacterial genome engineeringSemantic proximity
Development of a highly efficient base editing system for <i>Lactobacilli</i> to improve probiotics and dissect essential functionsSemantic proximity
Engineering <i>Escherichia coli</i> Nissle as safe chassis for delivery of therapeutic peptidesSemantic proximity
Characterizing the activity of abundant, diverse and active CRISPR-Cas systems in lactobacilli.Semantic proximity
Multiplex CRISPRi-Cas9 silencing of planktonic and stage-specific biofilm genes in <i>Enterococcus faecalis</i>Semantic proximity
A broad-host-range CRISPRi toolkit for silencing gene expression in <i>Burkholderia</i>Semantic proximity
One-for-all gene inactivation via PAM-independent base editing in bacteriaSemantic proximity
Programmable and portable CRISPR-Cas transcriptional activation in bacteriaSemantic proximity
Expansion of the Prime editing Modality with Cas9 from Francisella novicidaSemantic proximity
Select a neighboring publication to make it the new centre.