Article

RIT2 reduces LRRK2 kinase activity and protects against alpha-synuclein neuropathology

2020-10-21

Abstract excerpt

In Parkinson’s disease (PD) misfolded alpha-synuclein (aSyn) accumulates in the substantia nigra, where dopaminergic neurons are progressively lost. The mechanisms underlying aSyn pathology are still unclear but hypothesized to involve the autophagy-lysosome pathway (ALP). LRRK2 mutations are a major cause of familial and sporadic PD, hyperactivate kinase activity and its pharmacological inhibition reduces pS129-a...

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Literature Corpus work: 94e6c746-2527-5c88-a3a1-de74c51fa099
DOI: 10.1101/2020.10.21.348144

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