Article

Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation

2024-10-17

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson disease-causing mutations in the LRRK2 gene hyperactivate LRRK2 kinase activity, leading to increased phosphorylation of a subset of RAB GTPases, which are master regulators of intracellular trafficking. In neurons, processive retrograde transport of autophagosomes is essential for autophagosome maturation and effective degradation of autophagosomal cargo in the axon. We found that kn...

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Literature Corpus work: 1ef10a96-c27f-53e1-932a-75011772f35e
DOI: 10.1101/2024.10.14.618089

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