Article

Multimodal single-cell analyses reveal molecular markers of neuronal senescence in human drug-resistant epilepsy

2024-12-12

Abstract excerpt

The histopathological neurons in the brain tissue of drug-resistant epilepsy exhibit aberrant cytoarchitecture and imbalanced synaptic circuit function. However, the gene expression changes of these neurons remain unknown, making it difficult for the diagnosis or to dissect the mechanism of drug-resistant epilepsy. By integrating whole-cell patch clamp recording and single-cell RNA sequencing approaches, we identi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 94e6bf03-e0b9-587f-a52a-71be315c5d18
DOI: 10.1101/2024.12.07.627313

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multimodal single-cell analyses reveal molecular markers of neuronal senescence in human drug-resistant epilepsyDOI 10.1101/2024.12.07.627313Read

Single-Nucleus Transcriptomics Reveals Cell Type-Specific Remodeling and Epilepsy-Associated MicrogliaSemantic proximity Read

Single Cell Transcriptomics of Refractory Epilepsy patients in ColombiaSemantic proximity Read

Identification and validation of senescence-associated secretory phenotype-related biomarkers in epilepsySemantic proximity Read

Prominent contributions of selective neuronal subtypes to pediatric drug-resistant focal dysplasiaSemantic proximity Read

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in miceSemantic proximity Read

Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsySemantic proximity Read

Deciphering epileptogenic and activity-dependent gene programs in the human brainSemantic proximity Read

RNA-seq analysis of hippocampal tissues reveals novel candidate genes for drug refractory epilepsy in patients with MTLE-HSSemantic proximity Read

Cellular rejuvenation protects neurons from inflammation mediated cell deathSemantic proximity Read

Non-microglial downregulation of <i>PLCG2</i> impairs synaptic function and elicits Alzheimer disease-related hallmarksSemantic proximity Read

Multi-modal characterization and simulation of human epileptic circuitrySemantic proximity Read

Layer V Neocortical Neurons From Individuals With Drug-Resistant Epilepsy Show Multiple Synaptic Alterations but Lack Somatic HyperexcitabilitySemantic proximity Read