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Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy

6 May 2024

Abstract excerpt

Abstract Cortical malformations such as focal cortical dysplasia type II (FCDII) are associated with pediatric drug-resistant epilepsy that necessitates neurosurgery. FCDII results from somatic mosaicism due to post-zygotic mutations in genes of the PI3K-AKT-mTOR pathway, which produce a subset of dysmorphic cells clustered within healthy brain tissue. Here we show a correlation between epileptiform activity in...

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PMID: 38710875
DOI: 10.1038/s41593-024-01634-2

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