Article

Prominent contributions of selective neuronal subtypes to pediatric drug-resistant focal dysplasia

2023-07-25

Abstract excerpt

About 75% cases of epilepsy begin during childhood, and 10 - 30% of pediatric epilepsy patients are resistant to drug treatment. The predominant seizure type in children is focal cortical dysplasia (FCD) which is highly associated with drug-resistant epilepsy, but its underlying cause is poorly understood. We performed single-cell RNA sequencing and patch-clamp recording on fresh brain tissues obtained from pediat...

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Literature Corpus work: 3be7e5d8-713a-5047-a094-1a66be7f42bf
DOI: 10.1101/2023.07.21.549980

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